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Expert Commentaries

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Anne Langsted

Lipoprotein(a) as a CVD risk factor

May 22, 2024

Dr Anne Langsted, Rigshospitalet, Copenhagen, Denmark

In recent years, there has been an upsurge of interest in Lp(a) as a result of the growing body of research supporting the association between elevated Lp(a) and cardiovascular disease (CVD).

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Ioanna Gouni-Berthold

Clinical trials targeting Lp(a)

April 9, 2024

After many years working with lipid-lowering drugs during their development, I am very happy that clinical trials are underway of multiple agents targeting Lp(a) – a protein which I have always found fascinating and which is at least six times more pro-atherogenic per particle than LDL. The novel agents that are now in development fall into three categories – antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs) and small molecules.

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