MicroRNA clues to Lp(a) lowering

Targeting the LPA gene via specific microRNAs (miRs) that control its expression appears a promising option for lowering Lp(a), in the light of data presented at the congress. Professor Gilles Lambert and Romuald Techer (University of La Réunion Medical School, Reunion Islands) reported results of research to investigate the ability of four miRs (miR-455-5p, miR-22-5p, miR-194-5p and miR-218-5p) to interfere with LPA mRNA and reduce translation of apo(a), the protein encoded by LPA that is a key component of Lp(a).^1,2