Journal updates

Should Lp(a) levels be measured more than once?

October 16, 2024

Variations in Lp(a) levels with time, recorded in a third of clinically stable patients attending a lipid clinic in Argentina, suggest that repeat measurements may be needed, especially in those with borderline elevated Lp(a) levels. This was the conclusion of Dr Pablo Corral and colleagues who carried out a retrospective analysis of Lp(a) levels in […]

New insights on Lp(a) testing around the world

October 9, 2024

Recently published results of Lp(a) studies in Japan, Pakistan and Poland are helping to build a more detailed picture of Lp(a) levels worldwide, together with broader insights on testing practices.

Should Lp(a) thresholds for CAD risk stratification be different for women and men?

September 23, 2024

Lp(a) may predict coronary artery disease (CAD) risk at a lower level in women than in men, according to results of a study of 1858 patients (53% female) attending cardiology and internal medicine outpatient clinics at a tertiary university hospital in Turkey.

Olpasiran shows prolonged Lp(a) lowering

August 30, 2024

Participants in the Phase 2, placebo-controlled, OCEAN(a)-DOSE trial of olpasiran, the siRNA that disrupts LPA gene expression, have shown sustained reductions in Lp(a) levels nearly a year after their last dose.

Ethnicity and deprivation affect Lp(a) testing in clinical practice

July 30, 2024

Black and Hispanic patients with or at risk of atherosclerotic cardiovascular disease (ASCVD) are less likely to have Lp(a) testing than White and Asian heritage patients, as are individuals on Medicaid or living in socioeconomically deprived neighbourhoods. This is the finding from a retrospective analysis of electronic medical records of adults treated through Columbia University […]

Higher Lp(a) linked to faster haemodynamic progression in aortic stenosis

July 22, 2024

Higher plasma Lp(a) concentrations are associated with faster rates of haemodynamic progression on echocardiography in patients with aortic stenosis. This is the finding from an analysis of five longitudinal clinical studies carried out from March 2001-April 2024 in Canada and the UK, in which progression was assessed by annualised change in peak aortic jet velocity, […]