Dr Gissette Reyes-Soffer, MD

Assistant Professor of Medicine, Department of Medicine, Division of Preventive Medicine and Nutrition, Vagelos College of Physicians and Surgeons, USA

Mid-career investigator examining the metabolic pathways that regulate lipid and lipoprotein metabolism in humans. After completing a research fellowship,  I obtained training in clinical translational research (completed a 2-year NIH CTSA KL2 award) through the Irving Institute for Clinical and Translational Research at Columbia University and conducted studies examining post-prandial lipemia in the Action to Control Cardiovascular Risk in Diabetes study. I developed and validated novel mass spectrometry methods to examine the secretion and clearance of isotope-labeled proteins (apoB, CETP, apo(a), PCSK9, ApoCII and ApoCIII) isolated from human blood. Globally there are less than five laboratories actively using these methods highlighting their importance to describe the mechanisms that regulate lipid and lipoproteins and their risk to cardiovascular and other diseases. My independent and collaborative work has led to additional studies that examine lipid metabolism of rare lipid mutations, with published work on the RX19 APOC3 and pending publications on studies of TM6Sf2 and APOC2 mutations in humans. I participate in various investigator initiated-industry funded and drug development research programs. Most recently, our laboratory completed NIH funded detailed studies examining Lp(a)-apo(a) and Lp(a)-apoB secretion and clearance. Through recent partnerships, we have expanded our fluxomic studies to include proteomic and lipidomic profiling within our enrolled cohorts, presentation at AHA-ATVB Scientific Sessions 2022. We have established collaborations that include the study of large diverse cohorts that can help link genetic phenotypes to functional studies of lipid metabolism.  We continue to increase collaborations that allow the use of available samples to understand further actions of Lp(a) in inflammatory processes as shown by  recent presentations (’22) at the Gordon Conference and Frederickson Lipid Meeting.  Our publications range in scientific scope in top journals such as the Journal of Clinical Investigation, Science Translational Medicine, Circulation, and most recently ATVB. I have a strong commitment to training  the next generation of diverse scientist,  highlighted by commitments to volunteerism (AHA, CUIMC) and development of Peer-mentoring initiative locally (ASPIRE!). ASPIRE! is a program that supports the CUIMC CTSA TRANSFORM Faculty in training.