In his introductory slide deck to Lp(a), Professor John Chapman reviews the structure, genetics, physiology and epidemiology of Lp(a), assays for Lp(a) measurement, and the association between elevated Lp(a) and atherosclerotic cardiovascular disease (ASCVD) and aortic valve stenosis. He also considers the effects of current lipid lowering agents on Lp(a) levels and the potential of novel therapeutics in development.